Strongly coupled fluid-structure interaction (FSI) between diluted slurry of water and CaCO3 particles and a polycarbonate tube was studied numerically. A steel piston was impacted on top of the slurry, causing the generation and propagation of flexural waves in the tube wall and pressure waves in the slurry. Considering homogeneous mixtures as slurry and using the Arbitrary Lagrangian-Eulerian method, FSI cases with different volume fractions of solid partic es were considered. It was revealed that the wave speeds in the slurry were lower than those in water and tended to decrease gradually with an increase in the volume fraction of the particles. On the other hand, the pressures were less dependent on the volume fraction of particles in the slurry. Numerical results agreed well with the theoretical results proposed by Han et al. (1998), and the main trend of our experimental findings was shown.